7. The pathogenesis of Friedreich cardiomyopathy: myocarditis
نویسندگان
چکیده
منابع مشابه
The Pathogenesis of Cardiomyopathy in Friedreich Ataxia
Friedreich ataxia (FA) is an autosomal recessive disease with a complex neurological phenotype, but the most common cause of death is heart failure. This study presents a systematic analysis of 15 fixed and 13 frozen archival autopsy tissues of FA hearts and 10 normal controls (8 frozen) by measurement of cardiomyocyte hypertrophy; tissue frataxin assay; X-ray fluorescence (XRF) of iron (Fe) an...
متن کاملMolecular pathogenesis of Friedreich ataxia.
Friedreich ataxia, the most common type of inherited ataxia, is itself caused in most cases by a large expansion of an intronic GAA repeat, resulting in decreased expression of the target frataxin gene. The autosomal recessive inheritance of the disease gives this triplet repeat mutation some unique features of natural history and evolution. Frataxin is a mitochondrial protein that has homologu...
متن کاملMYOCARDITIS AND CARDIOMYOPATHY Chagas myocarditis and syncope
A 37-year-old gentleman was transferred to the University of Virginia Health System for cardiac evaluation after presenting to an outside hospital following a syncopal event. The patient immigrated from Honduras 6 years ago. Witnesses at the patient’s workplace report that he dropped suddenly to the floor and was unconscious for approximately 30 seconds without tonic-clonic seizure activity. Th...
متن کاملPathology of Intercalated Discs in Friedreich Cardiomyopathy.
in patients with subdural hematomas (4 of 48 patients; 8.3%) and consisted of significant increase in subdural hemorrhage with clinical deterioration; no rehemorrhages occurred in other types of intracranial hemorrhage (0 of 61 patients; 0%) (p 1⁄4 0.04). No rehemorrhages occurred in the 32 patients who had neurosurgical intervention for their initial hemorrhage, compared to 4 recurrent hemorrh...
متن کاملPeripartum myocarditis and cardiomyopathy.
The clinical and pathologic features of 18 consecutive patients with peripartum cardiomyopathy at The Johns Hopkins Hospital were examined in an attempt to define the incidence of myocarditis and to determine its response to immunosuppressive agents. In addition to routine studies, patients were evaluated with echocardiography, nuclear ventriculography, right heart catheterization, and myocardi...
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ژورنال
عنوان ژورنال: Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
سال: 2015
ISSN: 0317-1671,2057-0155
DOI: 10.1017/cjn.2015.255